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Regina Bailey

Lung Cancer Gene Identified

By April 27, 2012

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Lung Cells
Image Credit: Louisa Howard

Mayo Clinic researchers have identified the gene responsible for the development and spread of non-small cell lung cancer. According to researchers, this type of cancer is the most common cause of cancer deaths in the United States. The lung cancer gene, matrix metalloproteinase-10 (MMP-10), is used by cancer stem-like cells to produce cancer cells that are insusceptible to current treatments. Enzymes produced by this gene work to degrade cells and tissues that surround tumors, resulting in cancer metastasis.

According to senior investigator Alan Fields, "Our data provides evidence that MMP-10 plays a dual role in cancer. It stimulates the growth of cancer stem cells and stimulates their metastatic potential. MMP-10 acts to keep these cancer stem cells healthy and self renewing, which also helps explain why these cells escape conventional chemotherapy that might destroy the rest of the tumor." The researchers also suspect that MMP-10 may be the reason for the survival of other human cancer stem cells including those associated with colorectal, melanoma, breast, renal, and prostate cancers.

Learn more about this study, see:


May 3, 2012 at 11:51 pm
(1) raymondchiinda says:

Thanks Regina,that is a good development on that discovery of MMP gene that cause cancer.

May 5, 2012 at 1:28 am
(2) Rajat kakran says:

When vitamin E alpha tocopherols helps in prevention from caner like colon and prostate and which is common in american diet
so,when lung cancer stem cells loose their ability to develop tumors and after this when the gene is given back to the cell they can form tumor again
so, if we give the sometype of treatment with the help of vitamin E alpha tocopherols at that time when lung cancer stem cells loose their ability to develop tumors,
perphaps we can get rid from this type of cancer because its a weak stage of cancer stem cell when they loose their abilti to develop tumors.
But first do this experiment on mice
its delicate
may be it works
Rajat kakran

May 5, 2012 at 2:45 am
(3) Jon York says:

Thank you Regina for your continued informative news!

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